Clinical Effectiveness of the United Application with bFGF and ACRSC on Postoperative Wound-healing in Treatment of Acne Scar Using Fractional Erbium Laser MCL30
Objective : To study effectiveness of the united application of bFGF and ACRSC on postoperative wound-healing in treatment of acne scar using fractional Erbium laser MCL30.
Methods : Sixty-six patients with acne scar were divided into control group (group A, 12 cases), ACRSC group (group B, 27 cases) and united treatment group (group C, 27 cases). All patients were treated 3 times with interval 2 months using fractional Erbium laser MCL30 and terminated whose skin was appearing little amount of bleeding or exudate. Postoperative wound-cooling with avene cicalfate spray was applied by 3 times a day, 20 minutes each time. Group A was only treated by fractional Erbium laser MCL30 with no drugs; group B was done with ACRSC (once per day) from postoperative 3rd day (1 month in total); and group C was applicated jointly with bFGF (3 times a day) from postoperative 4th hour and with ACRSC (once per day) from postoperative 3rd day (1 month in total). The results of effect and follow-up including exudation time, callus time, duration of erythema and Patient’s satisfaction in postoperative 3rd, 7th, 14th, 30th and 60th day were assessed by two doctors.
Results : There were no pigment loss, infection, scar hyperplasia,and other adverse reactions in the whole groups. There were no obviously statistical significance in redness, exudation time between B and A groups [(2.96±1.34) d vs (3.26±1.43) d, (2.09±0.59) d vs (2.45±0.65) d)] (P>0.05), while there were obvious differences compared group C with group A [(2.72±1.31) d vs (3.26±1.43) d, (1.99±0.63) d vs (2.45±0.65) d)] (P<0.05). Compared by decrustation and erythema,three groups have obvious differences (P<0.05).
Conclusion : It is a kind of feasible, safe, effective method on accelerating postoperative wound-healing with few side-effects, and has good cosmetic effect.
Clinical Observation on Exogenous Basic Fibroblast Growth Factor in Wound Recovery after Dermabrasion
Objective : To study the effects of exogenous basic fibroblast growth factor (bFGF) in the wound recovery after dermabrasion.
Methods : Conduct single-blind comparison observation on the wound recovery of dermabrasion in two groups respectively.
Results : Compared with control group, drying and recovery speed of all wounds in the treatment group (with spraying of bFGF on the wound after surgery) are faster by 0.5 to 2.5 days. After t test, difference in wound recovery time is significant.
Conclusion : Exogenous bFGF is conducive to wound recovery after dermabrasion.
Efficacy Observation of Treatment of Tacrolimus Ointment Combined with BFGF on Facial Steroid Dependent Dermatitis
Objective : To study the clinical efficacy of tacrolimus ointment combined with bFGF on facial steroid dependent dermatitis.
Methods : Divide 90 cases of subjects into two groups, applying treatment of tacrolimus ointment combined with bFGF to 45 cases in treatment group and only tacrolimus treatment to 48 cases in control group. Course of treatment lasts 4 weeks, during which efficacy is observed.
Results : Total efficacy rate of treatment group is 88.89%; total efficacy rate of control group is 66.67%. Efficacy difference between these two groups has statistical significance (P<0.05). Incidence of adverse reactions in treatment group is 4.44% (2/45); incidence of adverse reactions in control group is 26.67%(12/45).
Conclusion : In the treatment of tacrolimus ointment combined with bFGF on facial steroid dependent dermatitis,physical signs disappear early, clinical efficacy is evident and incidence of adverse reactions is low.
Observation on the Efficacy of Skin Grinding Combined with External Application of Basic Fibroblast Growth Factor in the Treatment of Superficial Scars
Objective : To explore the clinical efficacy of skin grinding combining with external application of basic fibroblast growth factor (bFGF) in the treatment of superficial scar.
Methods : From February 2010 to March 2015, 23 patients with superficial scar were treated with dermabrasion, then the wound was covered with vaseline gauze that accompanied by bFGF solution, and bandaged. Follow-up and curative effect evaluation were carried out after operation.
Results : After treatment, markedly effective results were observed in 18 cases, effective results were observed in 3 cases, ineffective results were observed in 2 cases, and the effective rate was 90.9%. All the patients were followed up for 1 to 8 months. The wound showed different degree of erythema and pigmentation after operation, and all of them obtained satisfactory results through active nursing and treatment.
Conclusion : Skin grinding combining with external application of bFGF can reduce the time of wound healing and inhibit the formation of scar tissue,the curative effect is reliable.
The BFGF Effect on The Bad Injured Skin Area after Bromhidrosis Surgery
Objective : The bFGF effect on the bad injured skin area after mini-incision bromhidrosis surgery is discussed.
Methods : 40 patients who didn't acquire good recovery after outpatient bromhidrosis surgery between Jan, 2004 and Dec, 2007 were selected and divided into two groups randomly, one treating group of 20 patients and the other as control group. Use bFGF partially on the treating group and routine treatment on the control group.
Results : The control group's wounds took 16 to 24 days to heal,18.6 ± 1.6 days in average,and the width of scar was 5 ± 1.3mm after 3 months. However, it took the treatment group 12 to 15 days to recover, 13.8 ± 1.1 days in average, and the width of scar was 3 ± 0.8mm after 3 months.
Conclusion : If bad injured skin area occurs after mini-incision bromhidrosis surgery,the usage of bFGF can shorten healing time and improve the appearance of scar.
The Clinical Study of Basic Fibroblast Growth Factor Stimulating the Wound Surface Healing
Objective : Our aims were to observe the effects of basic fibroblast growth factor (bFGF) on the burn wound,donor skin area for operation, and chronic wound surface, and to study the medication methods.
Methods : We divided the 128 patients into burn wound, donor skin, chronic wound surface groups according to the classification of wound surface. Apart from being treated in routine methods, test groups were treated with bFGF. The self-control method was adopted for burn and donor skin wound groups, while the chronic wound was studied by comparing the effects before and after the treatment in one individual. We observed the time of healing of wound surface and the change of blood routine, urine routine,hepatic and renal function.
Results : After the treatment of bFGF, the healing time of donor skin area and chronic wound surface was shortened obviously. Especially for the wound surface of deep partial thickness and donor skin wound of split-thickness, the healing time was shortened by 3 to 5 days comparing with the control group. The average effective rate of bFGF was 91.88% and no side effect was found.
Conclusion : bFGF can stimulate the healing of burn, injury of skin, and chronic wound surface. This effect was more significant in deep partial thickness burn wound, severe injury of skin (donor skin wound of split-thickness), and the chronic wound surface.
Treatment of Facial Scar with Skin Expansion Combining Basic Fibroblast Growth Factor and Sucralfate
Objective : To summarize the clinical experience of treatment of facial scar with skin expansion combining basic fibroblast growth factor and sucralfate.
Methods : From May 2001 to May 2009, 32 patients with facial scar were collected. For phase I, place expanders in normal skins near facial scar or in deltopectoral skin flap area, continue constant pressure expansion. At the same time, inject bFGF and sucralfate into the gap between the surface of the expander and the expansion tissue. For phase II, resect the scar and adopt expanded skin flap to transfer for repair.
Results : 32 cases of clinical application with full skin expansion. Begin water injection expansion 2 days after operation, and the average expansion time is 12 days. Skin flap survives well and repairs at one time. Follow up 26 cases during 1 to 8 years and the results are satisfactory.
Conclusion : Skin expansion combining basic fibroblast growth factor and sucralfate is an ideal method for the treatment of facial scar.