Clinical Observation of Fibroblast Growth Factor in the Treatment of Diabetic Foot Ulcer
Objective : To study on the efficacy of fibroblast growth factor in the treatment of diabetic foot ulcer.
Method : Take 41 patient of diabetic foot, randomly and openly grouped into test group and control group, and observed for half a month.
Result : After the dressing change in the test group, the wound surface is significantly reduced, and required days for healing are significantly shortened.
Conclusion : There’s better efficacy of fibroblast growth factor in the treatment of diabetic foot ulcer.
Observation of Nursing Diabetic Foot Ulcer (DFU) with Basic Fibroblast Growth Factor for External Use
Objective : To observe DFU nursing with the basic fibroblast growth factor for external use.
Methods : A total of 56 DFU patients without infection were received and treated by the People’s Hospital of Gaozhou and randomized into an observation group or a control group by numbers. The patients in the observation group received the basic fibroblast growth factor for external use while the patients in the control group received routine nursing. Then the efficacy in both groups was compared.
Results : The total effective rate of the observation group was higher than that of the control group, with statistically significant difference (P<0.05). The total satisfaction rate of the observation group was higher than that of the control group, with statistically significant difference (P<0.05).
Conclusion : Basic fibroblast growth factor for external use has significant efficacy in the treatment and nursing of DFU patients, and can improve patient satisfaction, thus being of high clinical significance.
Repair Effect of Epidermal Growth Factor Combined with Basic Fibroblast Growth Factor on Diabetic Wound Healing
Objective : To discuss therapy effect of diabetic wound by epidermal growth factor (EGF) combined with basic fibroblast growth factor (bFGF).
Methods : Twenty-nine cases with diabetic wound were selected from the center of Burn and Plastic Rehabilitation in Guangxi Medical University between May 2001 and March 2005. They all signed the consents voluntarily. These patients were randomly divided into 4 groups: EGF combined bFGF (E+F group, 7cases), EGF (E group, 8 cases), bFGF (F group, 6 cases) and saline (saline group, 8 cases). Fasting sugar of all cases were controlled below 11.1 mmol/L before dealing with the wound, infection in the wound site treated by antibiotic, pathologic granulation tissues scraped. EGF and bFGF were sprayed over the wound by 1500 IU per time and 720 AU per time in the E and F group respectively. The EGF was sprayed over the wound for 1500 IU per time in the E group. The bFGF was sprayed over the wound for 720 AU per time in the F group. The wound of saline group was wiped by saline. All wounds were bind up and dressing was replaced every other day. The wound-healing rate and granulation tissues in the wound site were both observed for 3,7 and 14 days after treatment.
Results : All the 29 patients with diabetic foot were involved in the result analysis. ①Compared with each group during different time post-treatment: on the 3rd day after treatment, the wound healing rates between every two groups were similar (P>0.05); on the 7th day, it was higher in the E+F group and E group as compared with the saline group (P<0.05). On the 14th day after treatment, it increased significantly in the E+F group, E group and F group as compared with the saline group (21.67±1.53)%, (33.50±1.56)%, (28.77±1.50)%, (23.73±1.20)% (P<0.01 or 0.05), and the increase in the E+F group was the most obviously. ②General observation condition of granulation tissues growth at different time after treatment: On the 3rd day and 7th day after treatment, the growth was similar in every group (P>0.05). On the 14th day, the granulation tissues of the E+F group grew better than that of the E group, F group and the saline group (P<0.05).
Conclusion : There is a synergistic effect of EGF combined with bFGF in diabetic wound therapy.