Clinical Observation on BFGF for the Treatment of Deep Burn Wounds
Objective : To observe the therapeutic effect of bFGF on the deep burn wounds
Medication method : The wound was debrided with 0.1% chlorhexidine, directly applied with mixed bFGF spray, and then dressed with petrolatum gauze. The wound in control group was debrided with 0.1% chlorhexidine, and then directly dressed with petrolatum gauze, also with dressing change once every other day.
① Wound appearance : After application of bFGF, rapidly reduced secretion was seen on the wound, without significant granulation or edema, rapid formation and extension of residual flaps was seen on the wound base, the surface was covered with new epidermis, firmly connected with the base, without avulsion or ulceration, and the healing surface was flat. For the control group, many liquid secretions were seen on the wound, with partial excoriation, with tissue granulation, edema and aging, and formation of flaps was slow.
② Wound healing time : After application of bFGF for treatment, all the 132 patients had the wound healing 3-5 days earlier in average than the control (P＜0.01), where 87 patients with deep burn wound II degree had the wound healing 3 days earlier in average than the control, and 45 patients with deep burn wound II degree to III degree had the wound healing 5 days earlier in average than the control.
Application of Basic Fibroblast Factor in Burn Wound
Objective : To observe the effect of Basic Fibroblast Growth Factor (bFGF) on the healing of burn wound.
Methods : From 2000 to 2001, eighty patients with second degree burn wounds and eight patients with postburn granulation tissue wounds were adopted in this study, and these patients were treated with bFGF in the way of sprinkling locally (150AU/cm). The eighty patients with early burn wounds were adopted as the self control group and another eight patients with postburn granulation tissue wounds were adopted as the control group which was routinely treated. The healing time of wounds and the local and systemic reactions were observed.
Results : The healing time of wounds was shorter with bFGF than that of the control group and there was significant difference between the two groups (P<0.05).
Conclusion : bFGF can obviously promote the healing of burn wound.
Basic Fibroblast Growth Factor in Treating Burns and Other Skin Injuries
Objective : To observe the healing effect of basic fibroblast growth factor (bFGF) on the burn wounds, skin-offering wounds, injured wounds and chronic wounds.
Methods : On the base of routine treatment, bFGF was added in trial group but control group was not added. One hundred and eighty-three patients suffering from abovementioned wounds were divided into two parts. In part A, 110 cases were subjected to the randomized auto-control trials. The healing effects of different region in the same wounds or symmetrical position wounds in the same body were observed. In part B, 73 patients were undertaken as open trials to investigate the promoting healing effects of bFGF. The healing time and healing rates in different time were observed.
Results : In shallow II degree burn wounds, the average healing time was (10.2±2.1) days when bFGF was employed, and (12.7±2.4) days for the controls. In deep II degree burn wounds, the average healing time was (16.1±3.2) days in the trials compared with (19.4±2.9) days in the controls. In the granulation wounds, skin-offering wounds, injured wounds and chronic wounds, the corresponding average healing time was (22.4±6.4) days, (12.4±3.8) days, (11.3±2.6) day s, (16.6±10.2) days for the trails, and (29.4±4.6) days, (15.7±4.4) days, (13.1±2.8) days, (20.4±9.8) days for the controls. The healing time was significantly shorter in bFGF group than the controls except chronic wounds. The total effective rate in bFGF group was 91.32%.
Conclusions : bFGF can promote the healing in burn wounds, skin-offering wounds, granulation wounds, injured wounds and chronic wounds.
Basic Fibroblast Growth Factor in Treating Burns and Other Skin Injuries
Objective : To explore the burns and skin damage in patients using basic fibroblast growth factor in the treatment of clinical effect.
Methods : 60 cases of our hospital observation group and control group 30 cases of patients with burns and skin damage were randomized into the control group given conventional treatment, applying basic fibroblast growth factor treatment observation group, the clinical effect of contrast between the two groups.
Results : Control group superficial II degree, deep II degree, donor sites and healing time granulation, trauma and chronic wounds were significantly higher than in the observation group; incidence of adverse reactions to 6.7% in the observation group was significantly lower than 33.3% in the control group (P<0.05).
Conclusion : Burns and skin damage in patients using the effect of basic fibroblast growth factor significantly after treatment.
Clinical Observation of BFGF in Treatment of II Degree Burns in Man
Objective : To observe the therapeutic effect of bFGF on II degree burn wounds in man.
Methods : In an open auto-controlled design, the adjacent or symmetrical burn wounds, granulation wounds and ulcer wounds with similar depth were adopted and the effects were compared between bFGF group and control.
Results : The average healing time was (14.08±2.47) days for superficial II degree burn wounds and (18.35±5.4) days for deep II degree burn wounds, which were 3.00 days and 3.90 days shorter than those of control wounds. The total effective rates of bFGF were 100% for superficial II degree burn wounds and chronic wounds, and 95.24% for deep II degree burn wounds.
Conclusion : bFGF could promote the healing of superficial, deep II degree burn wounds and chronic wounds and no ARDs were found.
Curative Effect Observation of Mupirocin Combined with BFGF Suspension for the Treatment of III Degree Burn Wound
Objective : To investigate the clinical efficacy and safety of the Meek and mupirocin ointment combined with bFGF mixed suspension on liquid in the treatment of III degree burn wounds.
Methods : January 2013 to January 2015, selected 36 cases in our hospital which had III degree burn patients with clinical data were retrospectively analyzed, and respectively using Meek skin grafting combined with mupirocin ointment treatment and Meek, and treatment of mupirocin ointment combined with bFGF suspension. The clinical efficacy and adverse reactions were observed and compared.
Results : The time of wound healing and skin graft in the observation group were lower than that in control group, but the survival rate of skin graft was higher than that of control group (P<0.05). The two groups had no adverse reactions, 1 cases of each group had allergic reaction and other adverse reactions.
Conclusion : On the basis of Meek skin grafting, combined with mupirocin and alkaline into fibroblast growth factor in the treatment of III degree burn wound could be safe and effective and clinical application prospect could be broad.
Pharmacoeconomics Evaluation of BFGF for Burn Wounds Degree II
Objectives : To evaluate the pharmacoeconomics of for burn wound degree II.
Methods : Database of clinical trial of against burn wound degree II was re-analyzed and their cost in case report form (CRF) was collected retrospectively. Incremental cost-effectiveness analysis was used to evaluate the pharmacoeconomics effectiveness of the Budget impact analysis was conducted in order to make innovative drug reimbursement decision.
Results : 2.78 days was ahead to recover in the treat group using with comparison with the control group. 934.53 Chinese Yuan could be saved from the total cost when 1 day was ahead to recover in the patient being treated by bFGF.
Conclusion : The bFGF is effective, safe and economic to treat burn wound degree II.
The Clinical Study of Basic Fibroblast Growth Factor Stimulating the Wound Surface Healing
Objective : To observe the effects of basic fibroblast growth factor on the burning, supplying skin area for operation, and chronic wound surface and to study the medication methods.
Methods : One hundred and sixty three patients were divided into burning, supplying skin, chronic wound surface groups according to the classification of wound surface. The patients were treated with routine methods. Experimental groups were treated by bFGF and nothing was used to the control groups. The contrast method of the first and second groups were randomly auto-contrast and of the third group w as comparing the effects between before and after the treatment in one individual. The time of healing of wound surface and the change of blood routine, urine routine, hepatic and renal function were examined.
Results : After the treatment with bFGF, the healing time of supplying skin area and chronic wound surface was shortened obviously. Especially in the wound surface of deep degree burning and partial thick supplying skin area, the healing time was shortened 3 to 5 days compared with the control group. The average effective percent of bFGF was 91.3% and no side effect was found.
Conclusion : The bFGF can stimulate the healing of burn, injured skin, and chronic wound surface. This effect is more significant in deep degree burning, severe injured skin (partial thick supplying skin area), and the chronic wound surface.