Objective : To explore the effect of basic fibroblast growth factor (bFGF) in large soft tissue defect healing and scar formation preventing of the maxillofacial and neck, providing basis for clinical application of using cytokines in wound healing.

Methods : Though using bFGF in three typical cases whose wound defects were larger and deeper, one of which is skin flap necrosis after malignant tumors surgery; another one is operation area of trapezius flap ruptured after rewirable; the third one is serious dog bites with infection. Continued to observe the process of wound healing.

Results : The wounds of all three cases are healing well, without scar and keloid formation.

Conclusion :bFGF has good effect in the large soft tissue defect therapy of maxillofacial and neck, even in serious wound condition, and also effective control the formation of scar tissues, cytokines have a positive effect in wound healing and scar formation controlling.

Objective : To investigate the effect of basic fibroblast growth factor (bFGF) on surgical incision healing.

Methods : The healing procedure of 72 cases of bFGF group and control group were observed and the healing time was analyzed by statistic methods.

Results : The first-class healing rate was much higher and the healing time was much shorter in the treated group than those of the control group.

Conclusion : Administration of bFGF in operation may improve first-class healing rate and shorten healing time.

Objective : To investigate incision fat liquefaction after belly operation of prevention and treatment method.

Methods : From January 2000 to December 2007, the treatment methods of patients with fat liquefaction after abdominal surgery were analyzed retrospectively. Group A: 13 cases were treated by traditional methods. Group B: 11 cases were treated with bFGF by spraying incision. Group C: 15 cases were treated with continuous negative pressure suction with incision tube.

Results : The average postoperative wound healing time of group B and C was shorter than that of group A (P<0.01).

Conclusion : BFGF intra-incision spraying and intra-incision negative pressure drainage are superior to traditional methods in treating incision fat liquefaction, and can shorten healing time.

Objective : To do professional early stage nursing for serious heart disease operation wounds.

Methods : To do nursing for possible subcutaneous fat necrosis of critically ill, old ages, diabetes, chronic disease and malnutrition patients ahead of time, and treat the section with bFGF.

Results : All of 13 cases of section fat liquefied were healed with no delay fester occurred.

Conclusion : It was proved through clinical observation that bFGF can accelerate the concrescence of wounds and thus reduce the work load of nursing.

Objective : To observe the curative effect by basic fibroblast growth factor (bFGF) in the treatment of traumatic wound.

Methods : A total of 80 patients with soft tissue defect wound were randomly divided into treatment group (basic fibroblast growth factor for external use group) and control group (normal surgical dressing group), with 40 cases in each group. Curative effects of the two groups were observed.

Results : The treatment group had better healing time, grade A healing rate, and incidence of adverse reactions than the control group, and the difference had statistical significance (P<0.05).

Conclusion : Basic fibroblast growth factor for external use can enhance wound healing and improve grade A healing rate of traumatic wound, and it can also reduce adverse reactions with precisely curative effect.

Objective : To investigate the effect of basic fibroblast growth factor and collagen sponge to treat serious blooding wound surface.

Methods : 148 patients with serious blooding wound surface were randomly divided into two groups, including associated group ( using basic fibroblast growth factor and collagen sponge, 74 cases) and control group ( using common treatment, 74 cases) . The treatment effects on 2, 4, 6 days after injured were observed.

Results : The average non-blooding wound surface area / whole wound surface area of associated group on 2, 4, 6 days after injured were 24.77%, 51.49% and 76.94%, respectively, whereas that of the control group were 17.73%, 25.87% and 49.94%, respectively. There was very remarkable difference between the two groups ( P<0.01). Conclusions: It is more effective and faster to treat serious blooding wound surface with basic fibroblast growth factor associated with collagen sponge than that with common methods.