Clincal Observation on the Effect of Locally Used BFGF on Epithelization in Sinuous Cavities Following Endoscopic Surgery
Objective : To investigate the therapeutic effect of basic fibroblast growth factor (bFGF) on epithelization in sinuous cavities following endoscopic surgery.
Methods : One hundred cases with chronic sinusitis and/ or nasal polyps were randomly divided into two groups following endoscopic surgery, with the cases in treating group treated by locally used bFGF plus routine procedures and medicines and those in controlling one treated only by routine procedures and medicines. Then, observed the process of epithelization in the operative cavities.
Results : The averaged duration was 48.3 ± 8.8 days for epithelization in sinuous cavities in treating group and that was 77.2±12.2 days in controlling group, with a very significant difference between them(P<0.01). However, the total effective rate was 92.0% in treating group and 82.0% in controlling one, with no significant difference between these two rates (P>0.05).
Conclusion : Locally used bFGF following endoscopic surgery can promote the process of epithelization in the surgical cavities with a significantly shortened duration of this process.
Effects of BFGF on the Nasal Mucosa after Endoscopic Sinus Surgery
Objective : To explore the effect of bFGF on nasal mucosa after ESS.
Methods : Ten cases of type I phase 3 chronic sinusitis were selected randomly. For each patient bFGF was intranasally used in o ne single nasal cavity a week after ESS. The other cavity, treated with nothing, was used as control. Scanning electron microscopy examinations of middle meatus mucosa were made 1, 1.5, 2 and 3 month after ESS.
Results : In the first month after operation ciliated cells in the mucosa swelled and lined unregularly, the cilia exfoliated. From the sixth week to the 2nd month ciliated cells lined more regularly and the number of cells as well as the tensity of cilia increased obviously but the cilia aligned in disturbance. In the 3rd month after ESS, the swell of mucosa subside completely and cilia of columnar epithelial cells moved in one direction, which meant the cilia recover the function.
Conclusion : bFGF can speed up the recovery of nasal mucosa both in number and in function after ESS.
Efficacy of BFGF Atomization Inhalation on Postoperative Sore Throat Following Oral and Maxillofacial Surgery under General Anesthesia
Objective : To observe the effect of basic fibroblast growth factor (bFGF) atomization inhalation on postoperative sore throat following oral and maxillofacial operation under general anethesia.
Methods : Forty patients in whom oral and maxillofacial operation trachea was removed under general anesthesia were randomly divided into treatment and control groups; the treatment group received bFGF 35000IU + normal saline 20 mL, compression inhalation, day 1, every 20min, continued for 3 d; the control group was given normal saline 5 mL + dexamethasone 5 mg + gentamicin 80000 U + chymotrypsin 4000 U, compression inhalation, twice a day, every 20 min, continued for 3 d. Occurrence of postoperative sore throat 12 h after operation was recorded and visual analog scale (VAS) of sore throat (swallowing) 12, 24, 48, 72 h after operation was measured. SPSS l4.0 software package was used for statistical analysis.
Results : The incidence of sore throat in the treatment group was significantly lower than that in the control group (P<0.01) 12 h after operation; sore throat (swallowing) VAS 12, 24, 48 and 72 h after operation in the treatment group were significantly lower than that in the control group (P<0.05).
Conclusion : BFGF atomization inhalation can reduce the incidence of sore throat and sore throat level in oral and maxillofacial surgery after endotracheal intubation.
The Effects of Basic Fibroblast Growth Factor on Prognosis of Onsillectomy with Electrocoagulation by Monopolarelectric Knife
Objective : To observe the effects of basic fibroblast growth factor on the wound healing of tonsil and alleviating postoperative pain prognosis of tonsillectomy with electrocoagulation by monopolarelectric knife.
Methods : 32 patients who were admitted to our hospital forbilateral tonsillectomy due to chronic tonsillitis or tonsillar hypertrophy were randomly divided into treatment group and control group. After operation, the treatment group was daubed evenly of recombinant basic fibroblast growth factor.
Results : The time of wound albuginea formation, healing condition of the wounds, the time of albuginea complete detach at 24h, 48h and 72h after the operation were compared between these two groups. Result shows that the difference of the time of albuginea complete detachment and pain scores after the operation are statistically significant (P<0.05).
Conclusion : The basic fibroblast growth factor can promote the healing of wounds caused by tonsillectomy with electrocoagulation by monopolar electric knife and alleviate postoperative pain, which is worth being widespread.
Therapeutic Effect of BFGF on Postoperative Rehabilitation after Functional Nasal Endoscope
Objective : To observe and analyze the clinical effect of the bFGF on postoperative rehabilitation after functional nasal endoscope.
Methods : 416 cases undergone functional nasal endoscopic surgery from June 2013 to June 2015 in our department were randomly divided into experimental group and control group. A gelatin sponge filled with bEGF was attached to the surgical area in the experimental group, and a gelatin sponge filled with physiological saline was attached to the surgical area in the control group. All patients were followed for 6 months, and the curative effect and adhesion of the area were evaluated at 1, 2, 3 and 6 month.
Results : The curative effect and adhesion of the area after 1, 2, 3 and 6 month in the experimental group is better and less severe than those of the control group respectively.
Conclusion : BFGF can accelerate epithelization, reduce adhesion, and improve the curative effect after nasal endoscopic surgery.